Abstract: PP2C-type protein phosphatases belong to a family of Ser-Thr protein phosphatases. They are kinds of monomeric enzymes that present in both prokaryotes and eukaryotes. Evidences indicated that PP2C was involved in the negative regulation of ABA signaling and several other stress signaling pathways. Category and the recent progress of PP2C in the regulation of stress signaling transduction pathway in plants were briefly summarized in this paper.