Abstract: The extraction of exotic plant ragweed (Ambrosia artemisiifolia L. ) was made as core material and the gelatin was used as shell material to make the extraction into microcapsules by the single coacervation method. It can prevent the extraction of ragweed from inactivation, which could be easily caused by external condition such as illumination and temperature. The microcapsule technique can improve the property of extraction. The results showed that the morphology of microcapsules was regular and integrated observed under scanning electron microscope (SEM) . Moreover, the core material was coated with shell material observed by the infrared spectrum analysis with Fourier transform infrared spectroscopy (FTIR). The association efficiency and loading capacity of the microcapsules determined by ultraviolet spectrophotometer were (44.79 ±1.36)% and (59.72 ±1.81)%, respectively. The medium diameter was 25.50 μm analyzed with laser diffraction particle size analyzer. And the results of thermogravimetric analysis (TGA) demonstrated that the thermal stability of the microcapsules was superior to the core material. Consequently, the microcapsules with the extraction can avoid the unstable defect of the natural extraction. In addition, the activity was also lengthened by this technique