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己唑醇衍生物的合成及其抑菌性能研究

王蓓 张丽丽 倪洁 许如庆 程康华

王蓓, 张丽丽, 倪洁, 许如庆, 程康华. 己唑醇衍生物的合成及其抑菌性能研究[J]. 北京林业大学学报, 2015, 37(4): 135-142. doi: DOI:10.13332/j.1000-1522.20140282
引用本文: 王蓓, 张丽丽, 倪洁, 许如庆, 程康华. 己唑醇衍生物的合成及其抑菌性能研究[J]. 北京林业大学学报, 2015, 37(4): 135-142. doi: DOI:10.13332/j.1000-1522.20140282
WANG Bei, ZHANG Li-li, NI Jie, XU Ru-qing, CHENG Kang-hua. Synthesis and antimicrobial activities of hexaconazole derivatives[J]. Journal of Beijing Forestry University, 2015, 37(4): 135-142. doi: DOI:10.13332/j.1000-1522.20140282
Citation: WANG Bei, ZHANG Li-li, NI Jie, XU Ru-qing, CHENG Kang-hua. Synthesis and antimicrobial activities of hexaconazole derivatives[J]. Journal of Beijing Forestry University, 2015, 37(4): 135-142. doi: DOI:10.13332/j.1000-1522.20140282

己唑醇衍生物的合成及其抑菌性能研究

doi: DOI:10.13332/j.1000-1522.20140282
基金项目: 

林业公益性行业科研专项(201104032)、江苏高校优势学科建设工程项目。

详细信息
    作者简介:

    第一作者: 王蓓。主要研究方向:木材防腐剂。Email:826951544@qq.com 地址:210037 南京市龙蟠路159号南京林业大学化学工程学院木材保护研究所。责任作者: 程康华,教授。主要研究方向:木材防腐。Email: chengkh54@163.com。地址:同上。

    第一作者: 王蓓。主要研究方向:木材防腐剂。Email:826951544@qq.com 地址:210037 南京市龙蟠路159号南京林业大学化学工程学院木材保护研究所。责任作者: 程康华,教授。主要研究方向:木材防腐。Email: chengkh54@163.com。地址:同上。

Synthesis and antimicrobial activities of hexaconazole derivatives

  • 摘要: 为了提高己唑醇的杀菌广谱性以及杀菌活性,参考己唑醇的化学结构,以戊酰氯和取代苯为原料,经傅克酰基化、Corey-Chaykovsky环氧化反应、开环反应得到8种化合物,所有化合物均经质谱和核磁共振氢谱确证。选取常用木材腐朽菌——白腐菌(彩绒革盖菌、乳白耙齿菌)、褐腐菌(密粘褶菌、绵腐卧孔菌)和霉菌——黑曲霉作为实验菌株,采用滤纸片法研究8种目标化合物的抑菌活性。结果表明:在质量分数0.5%~2.0%范围内,除化合物A4、A5外,其余化合物对彩绒革盖菌、乳白耙齿菌、密粘褶菌、绵腐卧孔菌和黑曲霉均有一定的抑菌效果,其抑菌能力随着药液浓度的增加而增强。通过与己唑醇对照可知,化合物C3总体抑菌效果最好,并优于己唑醇;化合物C2对腐朽菌的抑菌效果优于己唑醇,对黑曲霉的抑菌效果弱于己唑醇;化合物A1、A2、A3、C1的抑菌效果均弱于己唑醇;化合物A4、A5对木材腐朽菌和霉菌几乎没有抑制作用。可见,卤素(F、Cl)对苯环2,4-二位上的取代、叔醇碳上异丁基的引入均有利于提高目标化合物的抑菌活性。

     

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出版历程
  • 收稿日期:  2014-08-29
  • 修回日期:  2014-10-28
  • 刊出日期:  2015-04-30

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