Abstract: We investigate the morphological characteristics, regional distribution and relative frequency of endocrine cells in the digestive tract of sables (Martes zibellina), using immunohistochemical techniques of the streptavidinperoxidase method. Results show that seven types of endocrine cells were found, which mainly located between epithelial cells of gastric glands and intestinal glands. Only 5-hydroxytryptamin (5-HT) immunoreactive (IR) cells were detected in the large intestine. None of the endocrine cells was identified in the oesophagus of M. zibellina. Most of the endocrine cells in the cardia gland, fundic gland, ileum, cecum and rectum were round to ellipse in shape, while those in the pylorus, duodenum, jejunum and colon were cuniform or spindle in shape. Among these endocrine cells, 5-HT-IR cells were detected throughout the entire gestrointestinal tract, while the distribution of other six types of endocrine cells was restricted. Most of the endocrine cells in M. zibellina reflected similar distribution patterns compared with other mammals. But the distribution pattern of somatostatin (SS) IR cells and substance P (SP) IR cells were different to that of the other mammals and may be the main characteristics of endocrine cells in the digestive tract of M. zibellina. 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