植物源挥发物-蒎烯微胶囊制剂的制备
Preparation of -pinene microcapsulation.
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摘要: 以壳聚糖和阿拉伯胶为壁材,采用复凝聚法制备挥发物-蒎烯微胶囊制剂。通过单因素考察和正交试验获 得微胶囊的最佳制备工艺条件。结果表明:壁材壳聚糖和阿拉伯胶的质量分数分别为0.2% 和3.5%,乳化剂体积 分数为2.5%,芯壁材质量比为1:1,反应温度为45 c,pH 值为4.5,凝聚时间为60 min 及搅拌转速为770 r/ min 为 最佳制备工艺条件;在此条件下,可形成壁膜表面致密、大小均匀的球形微胶囊,其平均粒径为5 m 左右,包埋率 与载药量分别为(51.70 2.5)%和(42.11 2.3)%,微胶囊能够明显延长琢鄄蒎烯释放时间,延长其活性,从而拓展 其应用范围。Abstract: An -pinene slow-release microcapsule with complex coacervation was prepared with chitosan and Arabic gum as wall materials. The optimal preparation process condition was obtained by applying a single-factor test and orthogonal experiment. The results showed that the concentrations of wall material and Arabic gum were 0.2% and 3.5%, respectively, emulsifier content was 2.5%, ratio of core and wall material was 1:1, reaction temperature was 45 c, pH was 4.5, time for coacervation was 60 min and stirring revolutions 770 round/ min were the best preparation process conditions. Uniform spherical microcapsules had an average particle size of 5 m. The encapsulation efficiency and drug loading were up to (51.70 2.5)% and (42.11 2.3)%. The microcapsule can extend releasing time of 琢-pinene, prolong its activity of time, thus expand its scope of application.
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Keywords:
- -pinene /
- complex coacervation /
- microcapsule /
- slow release
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