Abstract: The leaf of C₁₈Eucommia ulmoids contains varieties of compounds whose properties are quite different ranging from polarity to non-polarity.With kinds of isomers which are slightly different in nature, the same type of compounds are difficult to separate.Some compounds are strongly sensitive to heat or easy to oxidize, isomerize and decompose.On the basis of physicochemical properties and differences, countercurrent leaching is adopted and parameters such as temperature, solvent and its concentration, time, etc.are changed according to the demand.The total recovery ratio is 25%-27.5% and 11 compounds are isolated, they areβ-carotene, sodium copper chlorophyllin, pinoresinol diglucoside, chlorogenic acid, aucubin, dihydroflavonoids, chalcone, flavonol, acid polysaccharides, β-Sitosterol and gutta percha.The yield of drug active compounds is 11.19%-13.56%.